Halina Offner Selected Research

Stroke (Strokes)

1/2021	Major histocompatibility complex Class II-based therapy for stroke.
1/2020	A Novel Partial MHC Class II Construct, DRmQ, Inhibits Central and Peripheral Inflammatory Responses to Promote Neuroprotection in Experimental Stroke.
1/2020	Spleen participation in partial MHC class II construct neuroprotection in stroke.
12/2019	Sex differences in the therapeutic effects of anti-PDL2 neutralizing antibody on stroke.
1/2018	Uncovering the Rosetta Stone: Report from the First Annual Conference on Key Elements in Translating Stroke Therapeutics from Pre-Clinical to Clinical.
1/2018	Regulatory B cells in experimental stroke.
8/2017	Sex differences in regulatory cells in experimental stroke.
7/2017	Upregulation of CD74 and its potential association with disease severity in subjects with ischemic stroke.
7/2017	Partial MHC class II constructs as novel immunomodulatory therapy for stroke.
7/2017	Stroke and other cerebrovascular diseases.

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Halina Offner Research Topics

Disease

69	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 10/2023 - 01/2002
49	Multiple Sclerosis 01/2022 - 10/2002
33	Stroke (Strokes) 01/2021 - 05/2006
27	Inflammation (Inflammations) 10/2023 - 03/2002
19	Autoimmune Diseases (Autoimmune Disease) 01/2024 - 07/2002
13	Infarction (Infarctions) 01/2020 - 04/2010
11	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 01/2020 - 05/2006
8	Neuroinflammatory Diseases 01/2024 - 06/2007
6	Ischemic Stroke 12/2019 - 10/2014
5	Demyelinating Diseases (Demyelinating Disease) 01/2021 - 06/2010
5	Experimental Arthritis 06/2012 - 02/2004
4	Brain Ischemia (Cerebral Ischemia) 07/2017 - 05/2006
4	Encephalomyelitis (Myeloencephalitis) 01/2017 - 03/2002
4	Atrophy 09/2013 - 06/2006
4	Disease Progression 06/2010 - 02/2003
4	Rheumatoid Arthritis 06/2009 - 05/2004
3	Ischemia 01/2023 - 09/2013
3	Brain Injuries (Brain Injury) 10/2017 - 11/2007
3	Central Nervous System Diseases (CNS Diseases) 08/2015 - 09/2013
3	Arthritis (Polyarthritis) 06/2009 - 12/2003
2	Brain Infarction 01/2017 - 01/2014
2	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 05/2011 - 09/2008
1	Vascular Diseases (Vascular Disease) 01/2024
1	Neoplasms (Cancer) 01/2024
1	Mental Disorders (Mental Disorder) 01/2024
1	Myelitis 01/2023
1	Neuroblastoma 04/2022
1	Body Weight (Weight, Body) 01/2022
1	Astrocytoma (Pilocytic Astrocytoma) 12/2021
1	Dementia (Dementias) 12/2021
1	Brain Neoplasms (Brain Tumor) 12/2021
1	Nervous System Diseases (Neurological Disorders) 12/2021
1	Alzheimer Disease (Alzheimer's Disease) 12/2021

Drug/Important Bio-Agent (IBA)

30	Estrogens (Estrogen)FDA Link 02/2023 - 03/2002
28	Peptides (Polypeptides)IBA 10/2017 - 07/2003
28	LigandsIBA 10/2015 - 07/2003
26	T-Cell Antigen Receptors (T-Cell Receptor)IBA 02/2015 - 01/2002
19	CytokinesIBA 01/2021 - 09/2002
11	Estradiol (Delestrogen)FDA LinkGeneric 10/2015 - 03/2002
9	AntigensIBA 03/2012 - 10/2004
8	ChemokinesIBA 01/2021 - 03/2002
8	Therapeutic UsesIBA 01/2020 - 07/2003
7	Interleukin-10 (Interleukin 10)IBA 02/2023 - 09/2013
7	Gonadal Steroid Hormones (Sex Hormones)IBA 01/2017 - 02/2005
7	Estrogen Receptor alphaIBA 04/2010 - 10/2003
6	Macrophage Migration-Inhibitory FactorsIBA 01/2024 - 07/2017
6	HLA-DR2 Antigen (HLA DR2 Antigen)IBA 10/2014 - 07/2003
6	Myelin Basic ProteinIBA 05/2010 - 01/2003
5	Proteins (Proteins, Gene)FDA Link 10/2023 - 09/2005
5	Interleukin-6 (Interleukin 6)IBA 01/2020 - 09/2005
5	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 06/2009 - 03/2002
4	Biomarkers (Surrogate Marker)IBA 01/2024 - 07/2017
4	Interleukin-17 (Interleukin 17)IBA 06/2011 - 11/2007
3	Tissue Plasminogen Activator (Alteplase)FDA Link 01/2018 - 10/2014
3	Immunologic Factors (Immunomodulators)IBA 01/2018 - 04/2010
3	Messenger RNA (mRNA)IBA 07/2017 - 05/2006
3	AntibodiesIBA 10/2015 - 06/2010
3	HLA-DRB1 Chains (HLA DRB1)IBA 02/2015 - 09/2004
3	SteroidsIBA 05/2013 - 05/2010
3	Myelin-Oligodendrocyte GlycoproteinIBA 03/2012 - 07/2003
3	Ethinyl Estradiol (Estinyl)FDA LinkGeneric 04/2010 - 02/2003
3	Hormones (Hormone)IBA 04/2010 - 01/2004
3	Estrogen ReceptorsIBA 01/2010 - 03/2008
3	Histamine (Histamine Dihydrochloride)FDA Link 09/2008 - 03/2004
2	DRhQIBA 01/2023 - 01/2020
2	dopachrome isomeraseIBA 12/2021 - 10/2017
2	Neutralizing AntibodiesIBA 12/2019 - 01/2014
2	HLA Antigens (Human Leukocyte Antigens)IBA 10/2017 - 12/2015
2	Neuroprotective AgentsIBA 07/2017 - 04/2010
2	salicylhydroxamic acid (SHAM)IBA 01/2017 - 01/2016
2	Estriol (Epiestriol)IBA 01/2017 - 05/2013
2	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 12/2012 - 03/2008
2	Complement System Proteins (Complement)IBA 09/2011 - 09/2003
2	Histocompatibility Antigens Class IIIBA 05/2011 - 01/2008
2	InterferonsIBA 03/2011 - 10/2009
2	CollagenIBA 11/2010 - 06/2009
2	Collagen Type II (Type II Collagen)IBA 01/2008 - 05/2005
2	myelin proteolipid protein (139-151)IBA 09/2006 - 09/2005
2	Interleukin-2 (IL2)IBA 05/2006 - 03/2004
2	EpitopesIBA 10/2004 - 02/2003
2	5-androstene-16-fluoro-17-oneIBA 02/2004 - 09/2002
1	AntioxidantsIBA 10/2023
1	Factor XI (Plasma Thromboplastin Antecedent)IBA 10/2023
1	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 01/2023
1	tyrphostin A9IBA 04/2022
1	GAP-43 Protein (GAP 43 Protein)IBA 04/2022
1	NeurotoxinsIBA 04/2022
1	Adenosine Monophosphate (AMP)IBA 01/2022
1	MSH Release-Inhibiting Hormone (MIF-I)IBA 01/2022
1	Glucose (Dextrose)FDA LinkGeneric 01/2022
1	GenisteinIBA 01/2022
1	ProgranulinsIBA 12/2021

Therapy/Procedure

35	Therapeutics 01/2024 - 01/2003
3	Splenectomy 07/2018 - 01/2015
2	Thrombectomy 01/2018 - 07/2017
2	Aftercare (After-Treatment) 08/2015 - 09/2005
2	Immunotherapy 10/2014 - 01/2014
1	Euthanasia (Mercy Killing) 10/2023
1	Oral Administration 04/2022
1	Transplantation 01/2021